SPEAKER INVITATIONS - SEMINARS, SYMPOSIA AND CONFERENCES:

• Seminar at A*STAR Institute of Molecular and Cell Biology, Singapore. (Host: Prof Uttam Surana). June 11th 2013. Mitotic errors as a cause of DNA breaks and chromosome pulverisation.
• Seminar at Dept. of Biochemistry, National University of Singapore. (Host: A/P Yeong Foong May). June 12th 2013. Mitotic errors as a cause of DNA breaks and chromosome pulverisation.
• Seminar at Duke-NUS Graduate Medical School. (Host: Dr. Sang Hyun Lee). June 17th 2013. Mitotic errors as a cause of DNA breaks and chromosome pulverisation.
• Seminar at Cancer Science Institute, Singapore. (Host: Prof Daniel Tenen, Director of CSI). June 24th 2013. Small but dangerous: Errors in mitosis and chromosomal breaks.
• 43rd Annual Meeting of European Environmental Mutagen Society, Genome Integrity: From Mechanisms to Applied and Regulatory Research. Lancaster, UK. Title: DNA breaks and chromosome pulverization in mitosis (2014). 
• 7th Models of Physiology and Disease Annual Symposium. Department of Physiology, National University of Singapore, Singapore. Title: How do errors in mitosis contribute to tumours?  (2015).
• Seminar at Cancer Science institute, Singapore.  August 20th 2015. Autophagy-mediated senescence in response to anti-mitotics (2015).
• 74th Annual Meeting of the Japanese Cancer Association. Nagoya, Japan. Title: Autophagy-mediated senescence in response to anti-mitotics (2015). 
• Frontiers in Cancer Science 2015. Singapore. Title: Autophagy-mediated senescence supports survival upon treatment with anti-mitotics (2015).
• EMBO Workshop on Telomeric Chromatin and Telomere Fragility. Singapore. Title: Aneuploidy-induced telomeric breaks  (2015).
• 1st Autophagy Singapore Club (ASC) Symposia. Singapore. Title: Autophagy-mediated senescence during mitotic slippage (2016).
• JH/TTSH/LKCMed Symposium: Emerging Frontiers in Cancer Treatment. Tan Tock Seng Hospital, Singapore. Title: Mitotic slippage and its therapeutic implications following antimitotic drug treatment  (2016).
• Seminar at A*STAR Institute of Molecular and Cell Biology, Singapore. June 21st 2016. Title: Autophagy-mediated senescence in response to anti-mitotics (2016). 
• Frontiers in Cancer Science 2016. Singapore. Title: Mitotic slippage and its therapeutic implications following antimitotic drug treatment. (2016).
• Science improving Lives Symposium 2017. Nanyang Technological University, Singapore. Title: Understanding cancer through live-cell imaging of mis-segregated chromosomes.  (2017).
• International Symposium on Autophagy 2017. Singapore. Title: Autophagy governs pro-tumourigenic effects following mitotic slippage. (2017).
• BIOS2017. Mechanobiology Institute, National University of Singapore, Singapore. Title: Senescence paradox in anti-mitotic chemotherapy.(2017).
• TTSH-JH Oncology Conference: Emerging frontiers in cancer treatment: oncology in the geriatric patient. Tan Tock Seng Hospital, Singapore. Title: How does chemotherapy accelerate aging. (2017).
• ARISE Biology of Aging Research. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Title: Genome stability: insights into successful aging in nonagenarians. (2018).
• Abcam Meeting: Novel Insights into Nuclear Events in Cancer. Cancer Science Institute, Singapore. Title: Aneuploidy’s role in cancer. (2018).
• LKCMed-SCBE Joint Workshop. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Title: Age is just a number: how aneuploidy-triggered senescence drives cancer? (2018).
• 10th Models of Physiology and Disease Annual Symposium. Department of Physiology, National University of Singapore, Singapore. Title: Age is just a number: Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects (2018).
• 2nd ARISE Research Symposium on Healthy and Active Community and Ageing Workforce: Challenges, issues, and solutions. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Title: Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects  (2018).
• 2nd Singapore Autophagy Symposium. National University of Singapore, Singapore. Title: Autophagy mediates anti-mitotic drug-induced senescence and paracrine tumourigenic effects (2019).
• Japan-Singapore International Skin Conference 2019. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Title: Cell non-autonomous effects of chemotherapy-induced delayed wound healing (2019).
• ​The 94th Annual Meeting of the Japanese Biochemical Society. "New Trends in Cellular Senescence" Session. Nov 3rd-5th 2021, Yokohama,   Japan (Hybrid). Title: Exosomes from aneuploidy-induced senescent cells induce genomic instability (2021).
• 4th NUS-CMU National University of Singapore (Singapore)-China Medical University (Taiwan) joint symposium. Singapore (Online). Feb 24th-25th 2022.  ​Title: Cell autonomous effects of aneuploidy-induced senescence (2022).
• EMBO Workshop: The DNA damage response, immunity and aging. NUS Centre for Life Sciences, Singapore. Session: Cancer 1. Oct 10th-13th 2022. Title: Small Extracellular Vesicles from Therapy-Induced Senescent Breast Cancer Cells Elicit Paracrine Anti-Tumour Effects (2022).  ​
• NUSMedicine Healthy Longevity Webinar. Singapore (Online). May 11th 2023. Title: There is more to the senescence secretome than meets the eye (2023).  
• INSERM-InterAging Symposium. NUS Centre for Life Sciences, Singapore. Oct 18th-19th 2023. Title: Non-cell-autonomous impact: Differential immunomodulatory activity of therapy-induced senescence secretome (2023).
• Seminar at Okinawa Institute of Science and Technology (OIST). Okinawa, Japan. (Host: Dr. Keiko Kono). Oct 30th 2023. Title: Extracellular vesicles from paclitaxel-induced senescent TNBC elicit paracrine anti-tumour effects in a STING-dependent manner (2023).
• The 96th Annual Meeting of the Japanese Biochemical Society. Fukuoka, Japan. Oct 31st – Nov 2nd 2023. Session on Nov 2nd 2023: Biology of Aging. The novel knowledge of cellular response regulating aging and cellular senescence. Title: Exploiting senescence-associated extracellular vesicles for suppressing chemoresistance (2023).
• Cancer Research UK Cambridge Institute (CRUK-CI) Seminars in Cancer-Distinguished Lecturer Series. CRUK CI Lecture Theatre, Cambridge, UK. Oct 17th 2024. Title: Senescent secretome shenanigans:  Differential therapeutic benefit for breast cancer dictated by distinct extracellular vesicle-mediated inflammatory response (2024).
• NUS Centre for Cancer Research (N2CR) Thematic Seminar - Early Cancer Intervention. Online (Zoom). Nov 4th 2024. Senescent secretome shenanigans: differential inflammatory response dictated by senescent cancer cell-derived exosomes. 
• 6th NUS-CMU National University of Singapore (Singapore)-China Medical University (Taiwan) Joint Symposium.  NUS University Hall Auditorium. Nov 26th-27th 2024. Title: Differential therapeutic benefit for breast cancer dictated by distinct extracellular vesicle-mediated inflammatory response (2024).

ABSTRACT SELECTED FOR CONFERENCE ORAL PRESENTATION:  * Presenter Underlined. 

• EMBO Workshop on Cell Plasticity and Nuclear Dynamics. Singapore. Oct 12th-15th 2014. Elevating micronuclei formation contributes to post-slippage antiproliferative action of anti-mitotic drugs. Guo Ke, Cheng Bing and Karen Crasta. (2014).
• Quantitative Phase Imaging III. San Francisco, USA. Quantitative phase imaging of mitotic cells upon Noc treatment using d’Bioimager to govern cell fate. Guo Ke, Rosmin Elsa Mohan, Ruiqi Rachel Wang, Karen Crasta, Anand Asundi. (2017).
• International Cell Senescence Association (ICSA) Conference 2017, Paris, France. May 16th-19th 2017. Mitotic slippage-induced senescence confers a pro-tumourigenic phenotype. Cheng Bing and Karen Crasta.  (2017).
• Workshop on Computational Methods in Bio-imaging Sciences. Quantitative phase imaging of mitotic cells using d’Biomager.  Jan 2018: 8 (12) Anand Asundi, Karen Crasta, Rosmin Elsa, S. Sreelatha and Ajithkumar Patil (2018).
• International Society for Extracellular Vesicles (ISEV 2022) Annual Meeting, Lyon, France. May 25th-29th 2022. EVs from therapy-induced senescent breast cancer cells elicit STING-dependent inflammatory signaling. May 27th 2022. Session Name: OF17:EVs in breast and prostrate cancers. Matius Robert, Rekha Jakhar and Karen Crasta. (2022). ​
• The 7th International Cellular Senescence Association (ICSA) Conference. University Medical Centre Groningen, The Netherlands. Sept 29th-Oct 1st 2022. Title: Small extracellular vesicles from therapy-induced senescent breast cancer cells elicit STING-dependent inflammatory signalling.  Matius Robert, Rekha Jakhar and Karen Crasta. (2022). 
• Early Cancer Intervention: from Laboratory Discoveries to the Community Symposium 2024. National University of Singapore. May 13th-14th 2024. Session on "Early Carcinogenesis Research" May 13th. Extracellular vesicles within a tumourigenic senescent tumour secretome are able to confer antitumour immunity. Matius Robert, Rekha Jakhar and Karen Crasta (2024). ​

        
ABSTRACT SELECTED FOR CONFERENCE POSTER PRESENTATION: * Presenter Underlined. 

• AACR Precision Medicine Series: Synthetic lethal approaches to cancer vulnerabilities. Bellevue, WA, USA. May 17th-20th 2013. Karen Crasta. Autophagy diverts mitotic cell death with anti-mitotic drugs (2013).
• AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. Hynes Convention Center, Boston, USA. Oct 19th-23rd 2013. Karen Crasta. Autophagy diverts mitotic cell death with anti-mitotic drugs (2013).
• 108th International Titisee Conference on “Causes and Consequences of Aneuploidy”. Oct 23rd-27th 2013. Titisee, Black Forest, Germany (2013).
• Frontiers in Cancer Science 2013. Singapore. 5th-7th 2013. Karen Crasta. Autophagy diverts mitotic cell death with anti-mitotic drugs (2013).
• EMBO Workshop on Cell Plasticity and Nuclear Dynamics. Singapore. Oct 12th-15th 2014.  Guo Ke, Cheng Bing and Karen Crasta. Elevating micronuclei formation contributes to post-slippage antiproliferative action of anti-mitotic drugs (2014). 
• APOCB Congress and ASCB Workshops. Singapore Guo Ke, Cheng Bing and Karen Crasta. Elevating micronuclei formation contributes to post-slippage antiproliferative action of anti-mitotic drugs (2014).
• AACR Precision Medicine Series Drug Sensitivity and Resistance Improving Cancer Therapy. Orlando, USA (2014).
• EMBO Gold Medallist Symposium 2015. Biopolis, Singapore. Cheng Bing, Guo Ke and Karen Crasta.  Autophagy mediates senescence and supports survival upon treatment with antimitotics (2015).
• AACR Metabolism and Cancer.  Bellevue, WA, USA. Cheng Bing, Guo Ke, Alex Wong and Karen Crasta. Autophagy mediates senescence and supports survival upon treatment with anti-mitotic drugs (2015).
• 44th Annual Meeting of European Mutagenesis and Genomics Society. Prague, Czech Republic. Katharina Taichrib, Henning Hintzsche, Helga Stopper and Karen Crasta. Haematopoietic chromosomal instability and cell fate upon anti-mitotic drug treatment (2015).
• Frontiers in Cancer Science 2015. Singapore. Autophagy-mediated senescence supports survival upon treatment with anti-mitotics (2015).
• Keystone Symposium on Autophagy: Molecular and Physiological Mechanisms. Whistler, British Columbia, Canada. Karen Crasta, Cheng Bing and Guo Ke. Autophagy-induced senescence upon antimitotic therapy promotes paracrine tumorigenic effects (2016).
• International Cell Senescence Association (ICSA) 2016: Cellular Senescence: From Mechanisms to Therapeutic Opportunities. Weizmann Institute of Science, Israel. Karen Crasta, Cheng Bing and Guo Ke. Autophagy-induced senescence and chemoresistance following anti-mitotic therapy (2016).
• Asia Pacific Geriatrics Conference 2016. Singapore. CN Tan, PK Lieu, S Yew, WS Lim, E Wong, KC Crasta and MS Chong. Nutrition as a determinant of successful aging (2016).
• American Society for Cell Biology (ASCB) 2016. San Francisco. Karen C. Crasta, Bing Cheng, Ke Guo.  Autophagy governs tumourigenic effects following mitotic slippage (2016).
• American Association for Cancer Research (AACR) Annual Meeting 2017, Washington DC. USA. Karen C. Crasta, Bing Cheng, Ke Guo.  Autophagy governs tumourigenic effects following mitotic slippage (2017).
• International Cell Senescence Association (ICSA) Conference 2018. Montreal, Canada. He Qianqian, Monique Luijten and and Karen Crasta. Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects (2018).
• Keystone Symposia on Mitochondria in Aging 2019. Keystone, Colorado, USA. Karen Crasta. Mitochondrial dysfunction during mitotic slippage following treatment with anti-mitotic drug (2019).
• American Association for Cancer Research (AACR) Annual Meeting 2019, Atlanta USA. Alex Wong and Karen Crasta.  Lipid metabolism is involved in mitotic slippage-induced SASP upon treatment with anti-mitotic drugs (2019).
• International Society for Extracellular Vesicles (ISEV) 2019.  Kyoto, Japan. Rekha Jakhar, Joycelyn Teo and Karen Crasta. Exosomes from mitotic slippage-induced senescent cells stimulate inflammatory response (2019).
• AACR International Conference New Horizons in Cancer Research. Shenzhen, China. Rekha Jakhar, Joycelyn Teo and Karen Crasta. Exosomes from mitotic slippage-induced senescent cells stimulate inflammatory response (2019).
• The 6th International Cellular Senescence Association (ICSA) Conference. A new era of senescence research: the challenge of controlling aging and cancer. Osaka, Japan (Hybrid). Dec 12th-15th 2021. Rekha Jakhar, Matius Robert and Karen Crasta. Role of small extracellular vesicles in mediating paracrine activities of therapy induced breast cancer. (2021).
• Longevity Science Singapore Conference 2022. Singapore. Sept 7th-8th 2022. Matius Robert, Rekha Jakar and Karen Crasta. Role of small extracellular vesicles in mediating paracrine activities of therapy induced breast cancer (2022). 
• Australian Cell Cycle, DNA repair and Telomere Meeting. Melbourne, Australia. Oct 23rd-25th 2023. Matius Robert, Rekha Jakhar and Karen Crasta. Small extracellular vesicles from therapy-induced senescent breast cancer cells elicit paracrine anti-tumour effects in a STING-dependent manner (2023).
• Frontiers in Cancer Science 2023. University Cultural Centre, NUS. Nov 6th-8th 2023.  Matius Robert, Rekha Jakhar and Karen Crasta.  Small extracellular vesicles from therapy-induced senescent breast cancer cells elicit paracrine anti-tumour effects in a STING-dependent manner (2023).
• Singapore Zebrafish Meeting 2024. CeLS Auditorium Singapore. March 1st 2024. Rekha Jakhar, Raunak Sameer Vijayakar, Matius Robert, Qianhui Tan, Nathan Harmston, Karen C Crasta* and Ajay S Mathuru*. CCSER1: Unravelling its roles in mitosis, DNA repair and neuronal differentiation disorders (2024).
• 13th Models of Disease and Physiology Symposium. NUS MD11 CRC Auditorium.  Rekha Jakhar, Raunak Sameer Vijayakar, Matius Robert, Qianhui Tan, Nathan Harmston, Karen C Crasta* and Ajay S Mathuru*. Sept 26th-27th 2024. CCSER1 deficiency leads to mitotic defects and reduces genomic stability (2024). ​

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INVITED EDITORIAL ROLE:
Editorial Board Member of Scientific Reports (Cell Biology Division), Nature Publishing Group (2017-present).
Guest Editor, Endocrine-Related Cancer, Special issue for the 50th year of the Discovery of Tubulin (2017).
Associate Editor, Frontiers in Aging - Cancer and Aging (2020-present).
Guest Editor, Seminars in Cell and Developmental Biology, Special Issue on Chromothripsis (2021).
Guest Editor, Biomedicines MDPI, Special Issue on Cellular Senescence: Recent advances and discoveries (2023-2024).

INVITED PEER REVIEWER FOR GRANTS AND AWARDS: 
Singapore Ministry of Education (MOE) AcRF (2X), Singapore Millennial Foundation (SMF) Grant Call (2X), Singapore President Science and Technology Awards, Skin Innovation Grant, A*STAR-NHG-NTU Skin Research Grant (2X), NUS Equal Opportunities and Career Development (EOCD) Seed Grant Call, National Medical Research Council (NMRC)-YIRG (7X).

External Reviewer: Medical Research Council (MRC) New Investigator Research Grant (UK)(2X), Worldwide Cancer Research Fund International Grant Call (UK) (2X). 

AD-HOC JOURNAL REVIEWER: 
EMBO, Cell Reports, Cancer Research, Endocrine-related Cancer, Cell Division, Autophagy, Scientific Reports, European Biophysical Journal, Plos One, Experimental Brain Research, Clinical and Experimental Metastasis, Molecular and Cellular Biology, Molecular Biology of the Cell, Cell Communication and Signaling, iScience.

UNDERGRADUATE AND POSTGRADUATE STUDENT THESIS ADVISORY AND EXAMINATION COMMITTEES:
PhD Thesis Advisory Committees: 11 NTU students (2015-2019). Joined NUS> 1 NUS student, 1 NTU student (2020), 2 NUS Students (2022),  2 NUS Students (2023), 1 NUS, 1 A*STAR student (2024).
Qualifying Examination Committees: 2 students (2015),  3 students (2016), 2 students (2017), 7 students (2018), 1 student (2019), Joined NUS> 2 students (2020), 2 students (2021), 2 students (2022), 2 students (2023), 2 students (2024).
NUS Honours Project in Life Sciences (LSM4199) Examination: 1 student (2020), 1 student (2021), 2 students (2022), 1 student (2023), 1 student (2024).
NUS UROPS (LSM3288): Supervisor: 2 students, Examiner: 2 students (2024).
NUS Graduate Research Seminar (MDG5771): 1 student (2022)
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PHD THESIS DISSERTATION EXAMINATION COMMITTEES:
Local Thesis and Oral Examiner: 2 students (2015), 1 student (2017), 1 student (2019), Joined NUS> 1 student (2020), 3 students (2021), 1 student (2023),
2 students (2024)
External Thesis and Oral Examiner:  1 student (2014, NUS), 2 students (2015, NUS), 1 student (2016, NUS),  2 students (2019, NUS), 1 student (2019, City University of Hongkong, HK), 1 student (2023, University of Queensland, Australia).

UNIVERSITY-LEVEL AND SCHOOL COMMITTEES:
Selection Committee Member, LKCMedicine Postdoctoral Fellowship (2014).
Selection Committee Member, NITHM-IGS Systems Biology and Medicine PhD Program (2014-2015).
Member, LKCMedicine Space Allocation Committee (2015-2019).
Interview Panel Member, LKCMedicine PhD Selection (2016,2017).
Member-in-attendance, LKCMedicine School Management Board (SMB) Committee (2016-2020).
Organizing Committee Member, LKCMedicine Research Retreat (2017).
Taskforce Member, Integrating NHG CSSP and LKCMedicine PhD Program (2017).
Faculty Reviewer, LKCMedicine Phd Program Application (2017-2019).
Organizing Committee Member, Annual Frontiers in Cancer Science Conference (2017-2020).
Chairperson, EMB Research Facilities and Operations Committee (2017-2019).
Taskforce Member, LKCMedicine Research Strategy (2017-2019).
Executive Council Member, Women in Science and Healthcare (WISH), National University Health System (2021-2022).
Deputy Director, Academic Outreach, NUHS Research Office (2023-2026).

MISCELLANEOUS (SESSION CHAIR, POSTER JUDGE, STUDENT AND PUBLIC OUTREACH, ETC): 

• LKCMedicine Faculty Member, Welcome Reception for Inaugural Cohort of LKCMedicine MBBS Students at Research Techno Plaza (RTP) (2013).
• LKCMedicine Faculty Member, Inaugural White Coat Ceremony (2013).
• Chair, LKCMedicine Inaugural Brown Bag Seminar Series (2013). 
• Poster Judge, Frontiers in Cancer Science (2014).
• NTU Ambassador, L’oreal-UNESCO Women in Science Singapore, GIRLS2PIONEERS Program (2014-2020).
• Presented LKCMedicine Research Strategy to President of Singapore Dr Tony Tan and VIP Delegates, LKCMedicine Experimental Medicine Building Foundation Stone Laying Ceremony. (2015)
• LKCMedicine Booth Exhibitor, NTU Fest 2015 and Science & Technology Exhibition (SG50) at Marina Bay (2015).
• Presented work to showcase LKCMedicine’s capabilities, Visit by National Cancer Centre Singapore (NCCS) (2015).
• My Lab Group selected to showcase lab capabilities, NTU Open House 2016 at NTU EMB (2016).
• LKCMedicine Faculty Representative to help Singapore shape roadmap for câncer research, National-Level Health and Biomedical Sciences (HBMS) Cancer Taskforce (By invitation only) (2016).
• LKCMedicine Faculty, Sharing session with parents on LKCMed Undergraduate Program (2016).
• American Society for Cell Biology (ASCB) Ambassador for Singapore (2018-2020).
• Presented LKCMed Research Strategy to Visiting Delegates, Global Young Scientists Summit (GYSS) 2018 Site Visit (2018).
• Session Chair, Frontiers in Cancer Science (2018).
• Invited Key Speaker, Life Sciences Research Talks, Singaporean Researchers Global Summit (2019).
• Presentation Judge at NUS Physiology, Science Pitch Day (2021). 
• Invited Judging Evaluation Panel Member of Singapore Global Young Scientists Summit 2022 Video Contest (2022)
• Interviewed by The Straits Times newspaper as External Expert to comment on Aging study (Oct 22nd 2022)
• SINDA "Let her Shine" Program, Career Mentor (2023 - present). 
• Lab Outreach Program - A day in the Life of a Scientist. June 21st 2023. Visit by International French School (IFS) Singapore (2023)
• Career Mentor, (Inaugural) Healthy Longevity Talent Incubator Program, 11th July 2023 (2023)   
• HLTRP Science Festival, 15th Nov 2023 : Reviewer for HLTRP Young Investigator Grant Proposal & Juror for "Scientist's Odyssey" Challenge (2023)

• Session Chair, "Unlock Healthy Longevity: Supplements" Conference, Session on Bioactives, Feb 29th-March 1st 2024 (2024)
• Session Chair, Early Cancer Intervention: from Laboratory Discoveries to the Community Symposium 2024.  Session Theme: Advancements in Early Diagnosis and Intervention Technologies. May 13th 2024 (2024). ​
• Career Pathway Talk hosted by CRUK Cambridge Institute Graduate Society (UK), Oct 17th 2024 (2024)