- Oct 1st 2024
Laura moved here from the UK where she had done a PhD investigating the role of collagen mutations in cardiovascular disease at the University of Glasgow with Prof Tom Van Agtmael. She also worked with Dr Lorraine Work and has experience with extracellular vesicles and stroke. She will carry out exosomal profiling of cancer-related ischemic stroke here - a clinical collaboration with neurologist Dr. Leonard Yeo. Excited to have you in the lab Laura and Welcome!
Sept 26th&27th 2024
13th Models of Physiology and Disease Symposium
MD11 Clinical Research Centre Auditorium
Dr. Rekha Jakhar will be presenting a Poster on our collaborative work with the Mathuru lab on "CCSER1 deficiency leads to mitotic defects and reduces genome stability". Do look out for it!
13th Models of Physiology and Disease Symposium
MD11 Clinical Research Centre Auditorium
Dr. Rekha Jakhar will be presenting a Poster on our collaborative work with the Mathuru lab on "CCSER1 deficiency leads to mitotic defects and reduces genome stability". Do look out for it!
- August 12th 2024
Alethea and Rachel join us for their UROPS Project. Both are from the Faculty of Science and are starting their final year this semester. Welcome, looking forward to having you in the lab!
- May 13th 2024
Amy is a third-year summer research exchange student from the University of Toronto, Canada who will be joining us for her URAPS Summer Project. She is here for six weeks and is interested in the role of senescence in chemoresistance. Have an enjoyable research experience with us Amy!
March 1st 2024
Early Cancer Intervention: From Laboratory Discoveries to the Community
NUS MD6 LT35
It was an honour for our lab to attend and participate in the inaugural N2CR Early Cancer Intervention Symposium. Mat presented a fantastic short talk on our work on senescent cell-derived sEVs and anti-tumour immunity in TNBCs. Karen was Session Chair for the "Advancements in Early Diagnosis and Intervention Technologies" Session. It was a pleasure to introduce George Hanna, Shao Huilin, Pierce Chow, Ni Qianqian and Cheong Jit Kong from MirXes. Other fabulous scientists whose talks we enjoyed and had the pleasure meeting were Robert Scharpf, Lim Chwee Teck, Li Jingmei, Jeffrey Halter, and Renu Balyan.
Early Cancer Intervention: From Laboratory Discoveries to the Community
NUS MD6 LT35
It was an honour for our lab to attend and participate in the inaugural N2CR Early Cancer Intervention Symposium. Mat presented a fantastic short talk on our work on senescent cell-derived sEVs and anti-tumour immunity in TNBCs. Karen was Session Chair for the "Advancements in Early Diagnosis and Intervention Technologies" Session. It was a pleasure to introduce George Hanna, Shao Huilin, Pierce Chow, Ni Qianqian and Cheong Jit Kong from MirXes. Other fabulous scientists whose talks we enjoyed and had the pleasure meeting were Robert Scharpf, Lim Chwee Teck, Li Jingmei, Jeffrey Halter, and Renu Balyan.
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March 1st 2024
Singapore Zebrafish Meeting 2024 Dr. Rekha Jakhar presented a poster entitled "CCSER1: Unraveling its roles in mitosis, DNA repair, and neuronal differentiation disorders" on our collaborative work with A/P Ajay Mathuru's lab. And she was awarded the People's Choice Best Poster Award! Mighty Proud of her! |
FEB 29TH - March 1st 2024 Unlock Healthy Longevity Conference: Supplements
Shaw Foundation Alumni House, NUS, Singapore
Karen was Chair of the Bioactives Session at the Unlock Healthy Longevity Conference. It was an honour to introduce and interact with outstanding scientists Prof Barry Halliwell, Prof Paul Robbins, Prof Laura Niedernhofer, Dr Cory Goldberg, and Prof Patricia Anna d'Alessio.
Shaw Foundation Alumni House, NUS, Singapore
Karen was Chair of the Bioactives Session at the Unlock Healthy Longevity Conference. It was an honour to introduce and interact with outstanding scientists Prof Barry Halliwell, Prof Paul Robbins, Prof Laura Niedernhofer, Dr Cory Goldberg, and Prof Patricia Anna d'Alessio.
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This pilot study will involve exosomal profiling of a specific subtype of stroke, cancer-related ischemic stroke, in the Singapore population. Although detrimental to health and debilitating to cancer patients, information related to cause, diagnosis and treatment is scant. We are grateful to the reviewers and the funding agency for the opportunity to uncover underlying mechanisms for potential downstream biomarker discovery. The grant is due to start in June 2024 and funding duration is for three years.
- JAN 26th 2024 GRANT AWARD SUCCESS!
This pilot study will involve exosomal profiling of a specific subtype of stroke, cancer-related ischemic stroke, in the Singapore population. Although detrimental to health and debilitating to cancer patients, information related to cause, diagnosis and treatment is scant. We are grateful to the reviewers and the funding agency for the opportunity to uncover underlying mechanisms for potential downstream biomarker discovery. The grant is due to start in June 2024 and funding duration is for three years.
Nov 6th-8th 2023 Frontiers in Cancer Science 2023
University Cultural Centre, NUS
Mat will be presenting a Poster on our work on sEVs and therapy-induced senescence in breast cancers. Do look out for it!
University Cultural Centre, NUS
Mat will be presenting a Poster on our work on sEVs and therapy-induced senescence in breast cancers. Do look out for it!
Oct 31st - Nov 2nd 2023
Invited Speaker at The 96th Annual Meeting of the Japanese Biochemical Society (JBS2023)
Fukuoka International Congress Center, Marine Messe Fukuoka B Hall
Dr. Karen Crasta is Invited Conference Speaker at the 96th Annual Meeting of the Japanese Biochemical Society under the "Biology of aging~The novel knowledge of cellular response regulating aging and cellular senescence" Symposium in Fukuoka, Japan. Her talk is entitled "Exploiting senescence associated extracellular vesicles for suppressing chemoresistance".
We are grateful to the Symposium organisers Prof. Akiko Takahashi and Dr. Keiko Kono for the kind Invitation to present our work.
Post-conference: Thanks Akiko and Keiko for being gracious hosts and brilliant organisation of the symposium. It was an honour to present our work here, and I benefited greatly from the entire JBS Conference with outstanding speakers sharing recent findings and superb science. It was a pleasure to reconnect and also meet fellow symposium speakers: Akiko Takahashi, Keiko Kono, Yoshikazu Johmura, Motoshi Hayano, Goro Katsuumi and Sho Sugawara. Looking forward to collaborations together!
Invited Speaker at The 96th Annual Meeting of the Japanese Biochemical Society (JBS2023)
Fukuoka International Congress Center, Marine Messe Fukuoka B Hall
Dr. Karen Crasta is Invited Conference Speaker at the 96th Annual Meeting of the Japanese Biochemical Society under the "Biology of aging~The novel knowledge of cellular response regulating aging and cellular senescence" Symposium in Fukuoka, Japan. Her talk is entitled "Exploiting senescence associated extracellular vesicles for suppressing chemoresistance".
We are grateful to the Symposium organisers Prof. Akiko Takahashi and Dr. Keiko Kono for the kind Invitation to present our work.
Post-conference: Thanks Akiko and Keiko for being gracious hosts and brilliant organisation of the symposium. It was an honour to present our work here, and I benefited greatly from the entire JBS Conference with outstanding speakers sharing recent findings and superb science. It was a pleasure to reconnect and also meet fellow symposium speakers: Akiko Takahashi, Keiko Kono, Yoshikazu Johmura, Motoshi Hayano, Goro Katsuumi and Sho Sugawara. Looking forward to collaborations together!
JBS2023 Biology of Aging Symposium Speakers: Motoshi Hayano, Yoshikazu Johmura, Akiko Takahashi, Keiko Kono, Karen Crasta, Goro Katsuumi and Sho Sugawara.
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Enjoyed the exquisite Speakers' Dinner at Hakata Motsunabe Yamanaka, Akasaka.
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Oct 28th-31st 2023
Invited Speaker at Okinawa Institute of Science and Technology (OIST) Dr. Karen Crasta is invited to present a Research Seminar at the OIST, Okinawa, Japan. Her talk and visit will be hosted by Dr. Keiko Kono. |
From being received at Naha airport, to interesting discussions during and post-seminar, and the amazing food and tour of beautiful Okinawa, this was such a memorable trip. OIST itself is a picturesque campus with world class, top-quality science. It was an honour being hosted by Dr. Keiko Kono and am truly grateful for the opportunity to share our findings at OIST. I also learnt about exciting ongoing work from talented members of the Kono lab (Yohsuke, Hana, Yatzu, Yuta, Kojiro, Shinju). It was also a tremendous privilege to meet fellow mitosis scientists: Franz Meitinger, Midori Ohta, and Tomomi Kiyomitsu, as well as Hitomi Ohtaki.
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Oct 23rd-25th 2023 2023 Australian Cell Cycle, DNA Repair and Telomere Meeting (ACDTM)
Karen presented a Poster on our work on therapy-induced senescence, sEVs and STING inflammatory response.
A truly memorable conference. No other conference can beat the organisation and intellectual mingling at the ACDTM conference – Australian science truly rocks!
Got the chance to discuss with several awesome scientists; Chair Andrew Deans (such a pleasure!), Shom Goel, Paul Clarke, Enaam Alghmadi, Matthew Jones, Tony Cesare, Brian Gabrielli, Peter Sicinski, Eiji Hara, Lee Wong, Kum Kum Khanna, Liz Caldon, Dmitry Ivanov, Anton Gartner, and fellow peeps from Singapore Maya Jeitany and Sia Wang Rong, among others.
Karen presented a Poster on our work on therapy-induced senescence, sEVs and STING inflammatory response.
A truly memorable conference. No other conference can beat the organisation and intellectual mingling at the ACDTM conference – Australian science truly rocks!
Got the chance to discuss with several awesome scientists; Chair Andrew Deans (such a pleasure!), Shom Goel, Paul Clarke, Enaam Alghmadi, Matthew Jones, Tony Cesare, Brian Gabrielli, Peter Sicinski, Eiji Hara, Lee Wong, Kum Kum Khanna, Liz Caldon, Dmitry Ivanov, Anton Gartner, and fellow peeps from Singapore Maya Jeitany and Sia Wang Rong, among others.
Oct 18th-19th 2023 NUS-INSERM InterAging Seminar
InterAging 18th-19th Oct 2023. NUS Centre for Life Sciences, Singapore.
Dr. Karen Crasta is Invited Speaker at NUS-INSERM Interaging 2023.
Title of Talk:
Non-cell-autonomous impact: Differential immunomodulatory activity of therapy-induced senescence secretome.
Post-Conference Note:
A privilege to hear fantastic talks - was also lovely meeting Prof Jesus Gil again and learning about his group's exciting findings as always. Years ago, he was the one who first got me interested in senescence during a chance encounter at Imperial College London....
InterAging 18th-19th Oct 2023. NUS Centre for Life Sciences, Singapore.
Dr. Karen Crasta is Invited Speaker at NUS-INSERM Interaging 2023.
Title of Talk:
Non-cell-autonomous impact: Differential immunomodulatory activity of therapy-induced senescence secretome.
Post-Conference Note:
A privilege to hear fantastic talks - was also lovely meeting Prof Jesus Gil again and learning about his group's exciting findings as always. Years ago, he was the one who first got me interested in senescence during a chance encounter at Imperial College London....
June 28th 2023
And this just happened!!🥳
The National University of Singapore is in the top 1% globally!
Couldn't be more proud to be an alumna and a Scientist working here !! Awesome going to work everyday and mingling with the best minds !
And this just happened!!🥳
The National University of Singapore is in the top 1% globally!
Couldn't be more proud to be an alumna and a Scientist working here !! Awesome going to work everyday and mingling with the best minds !
June 21st 2023 - LAB OUTREACH
Happy to have Selma, Clemence and Sophia, three talented students from the International French School Singapore. They spent some time with Rekha and Mat to gain insights into how we tackle chemoresistance in cancer cells at our laboratory at the National University of Singapore, Yong Loo Lin School of Medicine!
Happy to have Selma, Clemence and Sophia, three talented students from the International French School Singapore. They spent some time with Rekha and Mat to gain insights into how we tackle chemoresistance in cancer cells at our laboratory at the National University of Singapore, Yong Loo Lin School of Medicine!
May 13th 2023
Karen is honoured to have been invited to serve as Career Mentor for SINDA's "Let Her Shine" Mentorship scheme.
Link to know more: https://www.sinda.org.sg/youth/mentorshiplhs/
"Being a Woman in Science and especially serving as a Mentor to young ladies interested in scientific research has always been of importance to me."
- Dr. Karen Crasta
May 11th 2023
Do tune in: Dr. Karen Crasta will be in conversation with Prof Andrea Maier about our ongoing work on therapy-induced senescence and extracellular vesicles at the Healthy Longevity Webinar Series May 11th 7pm-8pm (SG time).
(Special thanks to Webinar Director Joe Augustin)
In case you missed it, it will be on the NUSMedicine YouTube channel.
NUSMedicine YouTube Channel Link:
https://www.youtube.com/watch?v=zVilmosnfdU
Thanks for watching!
Do tune in: Dr. Karen Crasta will be in conversation with Prof Andrea Maier about our ongoing work on therapy-induced senescence and extracellular vesicles at the Healthy Longevity Webinar Series May 11th 7pm-8pm (SG time).
(Special thanks to Webinar Director Joe Augustin)
In case you missed it, it will be on the NUSMedicine YouTube channel.
NUSMedicine YouTube Channel Link:
https://www.youtube.com/watch?v=zVilmosnfdU
Thanks for watching!
- May 10th 2023 GRANT AWARD SUCCESS!
The pilot study examining effect of exercise-induced metabolic changes in breast cancer patients undergoing chemotherapy will be in collaboration together with Dr. Jorming Goh at Centre for Healthy Longevity and Dr. Elaine Lim at the National Cancer Centre. We are grateful to the Swee-Liew Wadsworth Foundation and the reviewers who reviewed our proposal.
Jan 2023: Welcome to the New Semester!!!
Interested to know more about the consequences of defective DNA damage response and repair pathway, and how to exploit them for cancer therapy??
Dr. Karen Crasta is teaching CDM5101 Feb 2023.
CDM5101 Fundamentals of Cancer Biology: DNA Damage, Repair and Cancer, Postgraduate Course
Interested to know more about the consequences of defective DNA damage response and repair pathway, and how to exploit them for cancer therapy??
Dr. Karen Crasta is teaching CDM5101 Feb 2023.
CDM5101 Fundamentals of Cancer Biology: DNA Damage, Repair and Cancer, Postgraduate Course
19th Jan 2023 PAPER ACCEPTED!
Pleasure and priviledge working with Suresh Jesuthasan, an exceptional brilliant neuroscientist and friend, and be a part of his team's collaborative work with Israel. Discovered a super-interesting mechanistic pathway involving exosomes for photoreceptor cell survival in the zebrafish pineal gland.
UPDATE, IT's OUT: Elazary Y, Cheow K, Cheng RK, Ghosh R, Shainer I, Wexler Y, Crasta K, Gothilf Y, Jesuthasan SJ. Glial cells expressing visual cycle genes are vital for photoreceptor survival in the zebrafish pineal gland. J Pineal Res. 2023 Jan 24:e12854. doi: 10.1111/jpi.12854. Epub ahead of print. PMID: 36692235.
NEXT IMMEDIATE STEPS: DECIPHERING CARGO AND DELINEATING FUNCTION! STAY TUNED!
Pleasure and priviledge working with Suresh Jesuthasan, an exceptional brilliant neuroscientist and friend, and be a part of his team's collaborative work with Israel. Discovered a super-interesting mechanistic pathway involving exosomes for photoreceptor cell survival in the zebrafish pineal gland.
UPDATE, IT's OUT: Elazary Y, Cheow K, Cheng RK, Ghosh R, Shainer I, Wexler Y, Crasta K, Gothilf Y, Jesuthasan SJ. Glial cells expressing visual cycle genes are vital for photoreceptor survival in the zebrafish pineal gland. J Pineal Res. 2023 Jan 24:e12854. doi: 10.1111/jpi.12854. Epub ahead of print. PMID: 36692235.
NEXT IMMEDIATE STEPS: DECIPHERING CARGO AND DELINEATING FUNCTION! STAY TUNED!
Silky, Karen, Rekha, Mat
Dec 13th 2022: Year-end Lab Lunch
MERRY CHRISTMAS AND
HAPPY HOLIDAYS!
MERRY CHRISTMAS AND
HAPPY HOLIDAYS!
Nov 4th 2022
Surprise visit by Bryan Lim to our lab!
Delighted to see Bryan again! Bryan is a Crasta Lab alumnus currently carrying out his PhD in Tumor Immunology at Duke University, Durham USA. He is in Singapore to attend the Frontiers in Cancer Science 2022 Annual Meeting. Do check out his poster! Mighty proud of him!
Post-conference note: Bryan was awarded a Poster Prize! Congratulations!
Surprise visit by Bryan Lim to our lab!
Delighted to see Bryan again! Bryan is a Crasta Lab alumnus currently carrying out his PhD in Tumor Immunology at Duke University, Durham USA. He is in Singapore to attend the Frontiers in Cancer Science 2022 Annual Meeting. Do check out his poster! Mighty proud of him!
Post-conference note: Bryan was awarded a Poster Prize! Congratulations!
Oct 24th 2022
Dr. Karen Crasta was interviewed by The Straits Times as an Expert from Centre for Health Longevity to comment on aging study:
https://www.straitstimes.com/singapore/sugar-makes-roundworms-live-longer-finding-could-help-to-slow-ageing-in-humans
Dr. Karen Crasta was interviewed by The Straits Times as an Expert from Centre for Health Longevity to comment on aging study:
https://www.straitstimes.com/singapore/sugar-makes-roundworms-live-longer-finding-could-help-to-slow-ageing-in-humans
October 10th-13th 2022: Invited Talk at EMBO Workshop
Venue: Centre for Life Sciences, Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore 117456
Dr. Karen Crasta is Invited Distinguished Speaker at the EMBO Workshop #DNAge happening at the National University of Singapore (NUS) and will be speaking about our latest findings on therapy-induced senescence.
Looking forward to the fantastic talks by experts in the field and interacting with all conference participants. Please Come Say Hello and we look forward to seeing all of you in Singapore!
Post-conference Note: It was such a delight getting to know first-hand research findings in the DDR, immunity and ageing space. Happy to have reconnected with old friends and made new ones. It was such a pleasure meeting Keiko Kono, Prof Eiji Hara, Hyunsook Lee, Aditi Gurkar, George Garinis, Nicolas Manel and Enaam Algamdi from Paul Clarke's UQ group. Conference dinner at Skai was amazing!
Venue: Centre for Life Sciences, Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore 117456
Dr. Karen Crasta is Invited Distinguished Speaker at the EMBO Workshop #DNAge happening at the National University of Singapore (NUS) and will be speaking about our latest findings on therapy-induced senescence.
Looking forward to the fantastic talks by experts in the field and interacting with all conference participants. Please Come Say Hello and we look forward to seeing all of you in Singapore!
Post-conference Note: It was such a delight getting to know first-hand research findings in the DDR, immunity and ageing space. Happy to have reconnected with old friends and made new ones. It was such a pleasure meeting Keiko Kono, Prof Eiji Hara, Hyunsook Lee, Aditi Gurkar, George Garinis, Nicolas Manel and Enaam Algamdi from Paul Clarke's UQ group. Conference dinner at Skai was amazing!
Sept 29th-Oct 1st 2022: ORAL PRESENTATION AT INTERNATIONAL CONFERENCE
Dr. Karen Crasta will be presenting at the 7th International Cell Senescence Association Conference (ICSA) in Groningen, The Netherlands (University Medical Centre Groningen).
Talk Title: Anti-Tumour Impact Of Small Extracellular Vesicles From Therapy-induced Senescent Breast Cancer Cells.
We thank ICSA Organisers Andrea Maier, Marco Demaria and Peter de Kaizer for selecting our abstract for oral presentation and look forward to an exciting conference.
Dr. Karen Crasta will be presenting at the 7th International Cell Senescence Association Conference (ICSA) in Groningen, The Netherlands (University Medical Centre Groningen).
Talk Title: Anti-Tumour Impact Of Small Extracellular Vesicles From Therapy-induced Senescent Breast Cancer Cells.
We thank ICSA Organisers Andrea Maier, Marco Demaria and Peter de Kaizer for selecting our abstract for oral presentation and look forward to an exciting conference.
Post-Conference Note:
ICSA 2022 at UMCG, Groningen was FABULOUS and one of the best conferences ever attended! Fantastic science with great talks and posters on the latest findings in senescence, with close interaction with experts in the field. Had fantastic conversations with Diana Jurk, Marco Demaria, Ana O' Loghlen, Cleo Bishop, Gerardo Ferbeyre, Francesco Fagglioli to name a few, as well as several talented junior research scientists Panos Galanos, Julia Majewska, Antonio Ahn, Maddy Tancock, Jamil Nehme, Boshi Wang, Eleanor Sheekey, Adelyne Chan, Beth Hughes, Danis Thomas, and many more.
On top of the unbeatable scientific experience, enjoyed the walking tour, Dutch dinner and pub experience, beautiful architecture and scenery and cyclists galore! A truly memorable ICSA conference!
ICSA 2022 at UMCG, Groningen was FABULOUS and one of the best conferences ever attended! Fantastic science with great talks and posters on the latest findings in senescence, with close interaction with experts in the field. Had fantastic conversations with Diana Jurk, Marco Demaria, Ana O' Loghlen, Cleo Bishop, Gerardo Ferbeyre, Francesco Fagglioli to name a few, as well as several talented junior research scientists Panos Galanos, Julia Majewska, Antonio Ahn, Maddy Tancock, Jamil Nehme, Boshi Wang, Eleanor Sheekey, Adelyne Chan, Beth Hughes, Danis Thomas, and many more.
On top of the unbeatable scientific experience, enjoyed the walking tour, Dutch dinner and pub experience, beautiful architecture and scenery and cyclists galore! A truly memorable ICSA conference!
Fantastic Poster Presentation by Mat.
7th and 8th Sept 2022: AND THE EVENT WE HAVE ALL BEEN WAITING FOR!!!
THE OFFICIAL OPENING OF THE CENTRE FOR HEALTHY LONGEVITY & INAUGURAL LONGEVITY SCIENCE SINGAPORE CONFERENCE !
HEAR FROM PROF BRIAN KENNEDY AND PROF ANDREA MAIER ALONG WITH AN EXCITING LINE-UP OF DISTINGUISHED SPEAKERS AND ESTEEMED PANEL MEMBERS ON SEPT 7th.
Matius Robert will be presenting a Research Poster on exciting findings related to EVs in therapy-induced senescence. Do check it out and come say Hello!
THE OFFICIAL OPENING OF THE CENTRE FOR HEALTHY LONGEVITY & INAUGURAL LONGEVITY SCIENCE SINGAPORE CONFERENCE !
HEAR FROM PROF BRIAN KENNEDY AND PROF ANDREA MAIER ALONG WITH AN EXCITING LINE-UP OF DISTINGUISHED SPEAKERS AND ESTEEMED PANEL MEMBERS ON SEPT 7th.
Matius Robert will be presenting a Research Poster on exciting findings related to EVs in therapy-induced senescence. Do check it out and come say Hello!
5th Sept 2022
Welcome Back Rekha! 🎉👏 Really happy to have Dr. Rekha Jakhar back in our lab. Rekha was stuck in India due to the pandemic for more than a year! She will work on a collaborative study with A/P Ajay Mathuru's lab, NUS Digital Medicine.
Welcome Back Rekha! 🎉👏 Really happy to have Dr. Rekha Jakhar back in our lab. Rekha was stuck in India due to the pandemic for more than a year! She will work on a collaborative study with A/P Ajay Mathuru's lab, NUS Digital Medicine.
22nd Aug 2022
WELCOME BACK Silky Hou whom we're excited to have back in the lab for her Capstone Project! Silky was previously with us in 2021 for her Yale-NUS Summer Research Project. Here's wishing you a productive and fun Capstone Project Year with us, Silky!
WELCOME BACK Silky Hou whom we're excited to have back in the lab for her Capstone Project! Silky was previously with us in 2021 for her Yale-NUS Summer Research Project. Here's wishing you a productive and fun Capstone Project Year with us, Silky!
Aug 2022: Welcome to the New Semester!!!
Dr. Karen Crasta is teaching NUS LSM3217 Human Ageing.
Topics covered: Biology of Aging, Genomic Instability, Cellular Senescence and Senolytics.
A fun informative course to sign up for!
Dr. Karen Crasta is teaching NUS LSM3217 Human Ageing.
Topics covered: Biology of Aging, Genomic Instability, Cellular Senescence and Senolytics.
A fun informative course to sign up for!
MAY 25th-29th 2022: ORAL PRESENTATION AT INTERNATIONAL CONFERENCE
Annual Meeting of International Society for Extracellular Vesicles (ISEV 2022), Lyon Convention Centre
Dr. Karen Crasta and Matius Robert will be at the Annual Meeting of International Society for Extracellular Vesicles (ISEV 2022) in Lyon, France
Karen's Talk: EVs from therapy-induced senescent breast cancer cells elicit STING-dependent inflammatory signaling
Session Name: OF17: EVs in Breast and Prostate Cancers. Session Date: Friday May 27, 2022.
We thank the ISEV Organisers for selecting our abstract for oral presentation, and are looking forward to an exciting conference and scientific travel after a really long time! Hope to see you there!
Post-Conference Note:
ISEV 2022 was amazing! Fantastic meeting Clotilde Thery, Lorraine O'Driscoll, Metka Lenassi, Kenneth Witwer, and catching up with Singapore EV peeps Prof Sai Kiang Lim, Minh Le, Wei Seong, Hou Han Wei.
Enriching experience learning about the latest findings in EV biology and technologies through many fascinating talks and posters.
Besides the science, also enjoyed the gastronomical delights, architecture and natural scenery of Lyon.
Annual Meeting of International Society for Extracellular Vesicles (ISEV 2022), Lyon Convention Centre
Dr. Karen Crasta and Matius Robert will be at the Annual Meeting of International Society for Extracellular Vesicles (ISEV 2022) in Lyon, France
Karen's Talk: EVs from therapy-induced senescent breast cancer cells elicit STING-dependent inflammatory signaling
Session Name: OF17: EVs in Breast and Prostate Cancers. Session Date: Friday May 27, 2022.
We thank the ISEV Organisers for selecting our abstract for oral presentation, and are looking forward to an exciting conference and scientific travel after a really long time! Hope to see you there!
Post-Conference Note:
ISEV 2022 was amazing! Fantastic meeting Clotilde Thery, Lorraine O'Driscoll, Metka Lenassi, Kenneth Witwer, and catching up with Singapore EV peeps Prof Sai Kiang Lim, Minh Le, Wei Seong, Hou Han Wei.
Enriching experience learning about the latest findings in EV biology and technologies through many fascinating talks and posters.
Besides the science, also enjoyed the gastronomical delights, architecture and natural scenery of Lyon.
4th National University of Singapore (Singapore) - China Medical University (Taiwan) Joint Symposium
Date: 24th and 25th February 2022
Dr. Karen Crasta has been invited to speak at this event.
Honoured to be speaking in the company of esteemed speakers!
LOOKING FORWARD TO THIS VIRTUAL ICSA CONFERENCE:
6th ICSA CONFERENCE
DEC 12th-15th 2021
A NEW ERA OF SENESCENCE RESEARCH:
THE CHALLENGE OF CONTROLLING AGING AND CANCER
LOOKING FORWARD TO THIS VIRTUAL ICSA CONFERENCE:
6th ICSA CONFERENCE
DEC 12th-15th 2021
A NEW ERA OF SENESCENCE RESEARCH:
THE CHALLENGE OF CONTROLLING AGING AND CANCER
Dec 1st-10th 2021 ASCB Conference 2021 (Virtual)
Missing meet up with Pellmanians but looking forward to online conference!
Missing meet up with Pellmanians but looking forward to online conference!
Cover image:
Mosaic tile art piece by Karen Crasta entitled “Chromosome in Chaos”. Chromothripsis (Greek, chromo for chromosome; thripsis, shattering
into pieces) is a mutational phenomenon where chromosome shattering leads to genome chaos (hodgepodge of colours in background). Broken
chromosome fragments with free ends (white bead-like structures with red ends) are rejoined haphazardly to form a massively-rearranged
chromosome.
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Editorial link: https://authors.elsevier.com/a/1e8aK3si8PnKmT Review by Matius Robert and Karen Crasta. Breaking the vicious circle: Extrachromosomal circular DNA as an emerging player in tumour evolution. Review Link: https://authors.elsevier.com/a/1e9xf3si8PnKkX |
Nov 4th 2021 INVITED INTERNATIONAL CONFERENCE TALK
Dr Karen Crasta has been invited to present our lab's latest findings as Invited Speaker at The 94th Annual Meeting of the Japanese Biochemical Society, Nov 3rd-5th 2021, "New Trends in Cellular Senescence" Session. (Virtual Event).
Program | The 94th Annual Meeting of the Japanese Biochemical Society (aeplan.co.jp)
Thank you for the opportunity to share our work!
Nov 1st-Nov 3rd 2021 Frontiers in Cancer Science 2021. 13th Annual Frontiers in Cancer Science International Conference. Registration Free! https://www.csi.nus.edu.sg/FCS/
Yet another exciting FCS this year!
We really enjoyed the online talks and great science by Clotilde Thery, Jesus Gil, Charles Swanton, Franklin Zhong, Melissa Fullwood, Lisa Tucker-Kellogg among many others!
Yet another exciting FCS this year!
We really enjoyed the online talks and great science by Clotilde Thery, Jesus Gil, Charles Swanton, Franklin Zhong, Melissa Fullwood, Lisa Tucker-Kellogg among many others!
- Sept 1st 2021
Truly thrilled about Matius Robert's joining as he's our FIRST New Staff recruit since we moved to NUS after MONTHS of COVID19-restrictions and delays! Mat is a recent graduate from the National University of Singapore and joins as a Research Assistant. WELCOME TO KC LAB, MAT!
- Aug 10th 2021 START OF NEW SEMESTER (AY2021/2022)
Dr Karen Crasta will be teaching HUMAN AGING (Module LSM 3217)
Lecture Wks: 10th-20th Aug, Tutorial: Sept, Personal Perspective on Aging: Oct 28th 2021.
- Aug 3rd 2021
Aliya is a final-year undergraduate student from NUS Faculty of Science joining us for her Honours Year Project. She will be studying exosomes in chromosomal instability. We are happy to have you in the lab, Aliya!
- July 12th 2021
Nabilah is a talented final-year undergraduate student from Yale-NUS joining the lab for her Capstone Project. She will be studying chromosome instability and stress response related to a novel cell cycle gene. Happy to have you with us, Nabilah!
- May 10th 2021
Silky is an undergraduate student from Yale-NUS on a Summer Research Program Attachment. She will be working on an exciting joint project between the Crasta Lab and the Mathuru Lab at Yale-NUS, exploring a novel player in the chromosome instability field. Happy to have you with us, Silky!
- Apr 26th 2021 GRANT AWARD SUCCESS!
We are grateful for the opportunity to elucidate mechanisms underlying micronuclear cell fates in aging together with A/P Mahmoud Pouladi's team and look forward to some really cool science !
- April 10th-15th 2021 American Association for Cancer Research Virtual Annual Meeting 2021
DISCOVERY SCIENCE PLENARY SESSION: MECHANISMS, IMPACT, AND EXPLOITATION OF CANCER CHROMOSOMAL INSTABILITY – DEDICATED TO THE MEMORY OF ANGELIKA AMON
CHAIR: ZUZANA STORCHOVA Saturday, April 10; 9:30-11:30 a.m. EDT
Mechanisms driving the rapid evolution of cancer genomes: David Pellman, Dana-Farber Cancer Institute, Boston, Massachusetts
Chromosomal instability and tumor evolution:Samuel F. Bakhoum, Memorial Sloan Kettering Cancer Center, New York, New York
Exploiting genome instability for new cancer therapies: PARP inhibitors and beyond: Stephen P. Jackson, University of Cambridge, Cambridge, United Kingdom
The causes and consequences of replication stress: Karlene A. Cimprich, Stanford University, Stanford, California
- Jan 1st 2021 Appointment to NUHS Women in Science and Healthcare ExCo!
LET THE BENCHWORK BEGIN! 🎀 Special shout-out to Raj, Andrea and Shaun - Thanks for being so helpful and welcoming.....we look forward to working with you! Kudos to Joycelyn and Rekha for getting the lab up and ready for work. Much thanks to Clarinda Lim and members of Brian Kennedy's Lab for their help in many ways. |
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- Dec 2nd-Dec 16th 2020
ONLINE ASCB-EMBO Annual Meeting
https://www.ascb.org/ascb-meetings/cell-bio-2020-an-ascbembo-meeting/
Missing the meet-up with Cell Biologist friends from the world over especially Pellmanians but Enjoyed the awesome talks and posters. (Another night event for this side of the world.... ). P.S. Recorded sessions available till Jan 15th !
And that's a wrap folks! Goodbye NTU!
Dec 1st 2020: GOODBYE NTU! HELLO NUS! 🎉
It's been challenging arranging a lab move during a pandemic but the Crasta Lab finally moves to the National University of Singapore!
We thank Prof Lim Kah Leong, Vice-Dean of Research at LKCMedicine for permitting us to use the space and facilities in the interim, and his kind help in many other ways. We will miss the many colleagues and friends we made during our stay at the LKCMedicine Experimental Medicine Building, and will cherish the memories and fun times shared as we set up this new medical school together. We are immensely grateful to the Singapore National Research Foundation (NRF) and Singapore Ministry of Education (MOE) for funding state-of-the-art equipment that will allow us to do best research possible at NUS! On to making new memories, meeting new colleagues and continuing important cancer research at NUS!
It's been challenging arranging a lab move during a pandemic but the Crasta Lab finally moves to the National University of Singapore!
We thank Prof Lim Kah Leong, Vice-Dean of Research at LKCMedicine for permitting us to use the space and facilities in the interim, and his kind help in many other ways. We will miss the many colleagues and friends we made during our stay at the LKCMedicine Experimental Medicine Building, and will cherish the memories and fun times shared as we set up this new medical school together. We are immensely grateful to the Singapore National Research Foundation (NRF) and Singapore Ministry of Education (MOE) for funding state-of-the-art equipment that will allow us to do best research possible at NUS! On to making new memories, meeting new colleagues and continuing important cancer research at NUS!
Nov 2020 Frontiers in Cancer Science 2020
12th Annual Frontiers in Cancer Science International Conference.
Nov 2nd-6th. Registration Free!
https://www.csi.nus.edu.sg/FCS/
Yet another fantastic Annual Frontiers in Cancer Science (FCS) Meeting this year! What a priviledge to attend with the very best local and international Cancer experts as always. Plus registration was FREE this year! Loved the talks by peeps I first met at Dana-Farber Cancer Institute, Rani George and Takaomi Sanda... and the introduction to breast pathology by Dr. Puay Hoon Tan. Was great to see Ashok Venkitaraman, new Director at NUS Cancer Science Institute (CSI), give the opening address.
12th Annual Frontiers in Cancer Science International Conference.
Nov 2nd-6th. Registration Free!
https://www.csi.nus.edu.sg/FCS/
Yet another fantastic Annual Frontiers in Cancer Science (FCS) Meeting this year! What a priviledge to attend with the very best local and international Cancer experts as always. Plus registration was FREE this year! Loved the talks by peeps I first met at Dana-Farber Cancer Institute, Rani George and Takaomi Sanda... and the introduction to breast pathology by Dr. Puay Hoon Tan. Was great to see Ashok Venkitaraman, new Director at NUS Cancer Science Institute (CSI), give the opening address.
- Oct 2020 Breast Cancer Awareness Month
- https://www.todayonline.com/commentary/tackling-breast-cancer-public-health-issue-singapore
- July 2020 PAPER ACCEPTED!
Bryan Lim and Karen Crasta contributed to work from A/P Yunn Hwen Gan's laboratory at NUS YLLSOM, Dept of Biochemistry. The work described a novel pathway for micronuclei-mediated cGAS-STING pathway in bacterial pathogenesis. Yet another cool role for micronuclei! Working with Joanne and Yunn was really enjoyable and discussions intellectually-stimulating! Thanks for the invitation to collaborate!
June 22nd-24th 2020
Put in an all-nighter again since we wanted to attend some talks first-hand, but will go through the recordings again as speakers/talks were so good.
These were among our stand-out favourites:
June 22nd
(1) Opening-Plenary-Session-Turning-Science-into-Lifesaving-Care
Age against the machine: How the aging microenvironment governs response to therapy: Ashani T Weeraratna
(2) Sessions > One of These Things Is Not Like the Other: The Many Faces of Senescence in Cancer
- Senescence, cancer and tumor immunity: A challenging relationship: Andrea Alimonti
- The dynamic nature of senescence in cancer and its therapeutic relevance: Clemens A Schmitt
- From pro-senescence to senolytic therapy for cancer: René Bernards
June 23rd
(1) Tumour Cell Dormancy
Defining tumor cell dormancy: Learning lessons from myeloma: Peter Croucher
What wakes up dormant cancer cells? Intrinsic versus extrinsic control: Mikala Egeblad
How to target the seeds that contribute to future relapses: Maria Soledad Sosa
(2) Noncoding RNA in Cancer Progression
Introduction: Ahmad M. Khalil
Epigenetic regulation of the human genome by lincRNAs: Ahmad M. Khalil
Long noncoding RNAs as functional molecules in cancer pathways: Maite Huarte
About Chomsky, patterns, noncoding RNAs, and cancer patients: George A Calin
Functions of noncoding RNA and protein interactions in cancer cells: Colleen A. McHugh
(3) The Wound Healing that Never Heals: The Tumor Microenvironment (TME) in Cancer Progression
The importance of vascular permeability in tumor stroma generation and wound healing: Harold F Dvorak
Aging in the driver’s seat: Tumor progression and beyond: Sheila A Stewart
Why won’t CAFs stay normal?: Edna Cukierman
- American Association for Cancer ResearchVirtual Annual Meeting II
Put in an all-nighter again since we wanted to attend some talks first-hand, but will go through the recordings again as speakers/talks were so good.
These were among our stand-out favourites:
June 22nd
(1) Opening-Plenary-Session-Turning-Science-into-Lifesaving-Care
Age against the machine: How the aging microenvironment governs response to therapy: Ashani T Weeraratna
(2) Sessions > One of These Things Is Not Like the Other: The Many Faces of Senescence in Cancer
- Senescence, cancer and tumor immunity: A challenging relationship: Andrea Alimonti
- The dynamic nature of senescence in cancer and its therapeutic relevance: Clemens A Schmitt
- From pro-senescence to senolytic therapy for cancer: René Bernards
June 23rd
(1) Tumour Cell Dormancy
Defining tumor cell dormancy: Learning lessons from myeloma: Peter Croucher
What wakes up dormant cancer cells? Intrinsic versus extrinsic control: Mikala Egeblad
How to target the seeds that contribute to future relapses: Maria Soledad Sosa
(2) Noncoding RNA in Cancer Progression
Introduction: Ahmad M. Khalil
Epigenetic regulation of the human genome by lincRNAs: Ahmad M. Khalil
Long noncoding RNAs as functional molecules in cancer pathways: Maite Huarte
About Chomsky, patterns, noncoding RNAs, and cancer patients: George A Calin
Functions of noncoding RNA and protein interactions in cancer cells: Colleen A. McHugh
(3) The Wound Healing that Never Heals: The Tumor Microenvironment (TME) in Cancer Progression
The importance of vascular permeability in tumor stroma generation and wound healing: Harold F Dvorak
Aging in the driver’s seat: Tumor progression and beyond: Sheila A Stewart
Why won’t CAFs stay normal?: Edna Cukierman
April 27th-28th 2020
We're missing the AACR Annual Meeting (the largest, most educational and informative cancer conference in the world!) for the first time in years. Chuffed that the organisers made it easy to attend online though - THANK YOU AACR !
As usual fantastic talks by awesome cancer scientists and oncologists!
- American Association for Cancer ResearchVirtual Annual Meeting I
We're missing the AACR Annual Meeting (the largest, most educational and informative cancer conference in the world!) for the first time in years. Chuffed that the organisers made it easy to attend online though - THANK YOU AACR !
As usual fantastic talks by awesome cancer scientists and oncologists!
April-July 2020 COVID! Lab shutdown :-(
(Singapore Circuit Breaker)
So our plans to move to NUS have been delayed again. This time foiled big-time by a tiny virus! Experiments have been literally "put in cold storage" as the lab will be shut down.
Will miss you, Lab Bench! See you in a few months while we stay safe at home....
A special shout-out and THANK YOU to all healthcare professionals and friends working so hard 💖www.youtube.com/watch?v=xGKFVMgjrPc
(Singapore Circuit Breaker)
So our plans to move to NUS have been delayed again. This time foiled big-time by a tiny virus! Experiments have been literally "put in cold storage" as the lab will be shut down.
Will miss you, Lab Bench! See you in a few months while we stay safe at home....
A special shout-out and THANK YOU to all healthcare professionals and friends working so hard 💖www.youtube.com/watch?v=xGKFVMgjrPc
- Feb 2020 THE CRASTA LAB STARTS AT NUS!
Well, at least on paper....We are in the final stages of packing and getting ready to move the lab from the NTU campus to NUS and are REALLY looking forward to join the Cancer and Aging scientific community at the Yong Loo Lin School of Medicine, Department of Physiology and the Healthy Longevity Translational Research Programme. Stay tuned for the move! 🥂