Publications
Below is a list of peer-reviewed publications arising from work led by the Crasta Lab, listed in reverse chronological order. Our research spans chromosomal instability, cellular stress responses, tumour–microenvironment interactions, and the cancer–ageing nexus.
Below is a list of peer-reviewed publications arising from work led by the Crasta Lab, listed in reverse chronological order. Our research spans chromosomal instability, cellular stress responses, tumour–microenvironment interactions, and the cancer–ageing nexus.
2026
Zhang S, Jiang Z, Yang Q, Zheng H, Wang M, Zhu C, Deng LW, Crasta KC, Liou YC. NuSAP safeguards centriole integrity to mediate CEP57–CEP152 torus recruitment for proper engagement. Advanced Science. 2026; e15192. https://doi.org/10.1002/advs.202515192
2025
Guan L, Zdantsevich K, Sandalova E, Crasta KC, Maier AB.
Dietary ingredients inducing cellular senescence in animals and humans: A systematic review. Mechanisms of Ageing and Development. 2025;112083.
https://doi.org/10.1016/j.mad.2025.112083
Halim CE, Deng S, Crasta KC, Yap CT.
Interplay between the cytoskeleton and DNA damage response in cancer progression. Cancers. 2025;17(8):1378.
https://doi.org/10.3390/cancers17081378
Glaviano A, Singh SK, Lee EHC, Okina E, Lam HY, Carbone D, Reddy EP, O’Connor MJ, Koff A, Singh G, Stebbing J, Sethi G, Crasta KC, Diana P, Keyomarsi K, Yaffe MB, Wander SA, Bardia A, Kumar AP.
Cell cycle dysregulation in cancer. Pharmacological Reviews. 2025;77(2).
https://doi.org/10.1016/j.pharmr.2024.100030
2024
Crasta KC, Faggioli F.
Editorial: Cellular senescence—recent cellular advances and discoveries. Biomedicines. 2024;12(12):2796.
https://doi.org/10.3390/biomedicines12122796
Glaviano A, Wander SA, Baird RD, Yap KC, Lam HY, Toi M, Carbone D, Geoerger B, Serra V, Jones RH, Ngeow J, Toska E, Stebbing J, Crasta KC, Finn RS, Diana P, Vuina K, de Bruin RAM, Surana U, Bardia A, Kumar AP.
Mechanisms of sensitivity and resistance to CDK4/6 inhibitors in hormone receptor–positive breast cancer. Drug Resistance Updates. 2024;76:101103.
https://doi.org/10.1016/j.drup.2024.101103
Robert M, Jakhar R, Au BV, Eng GWL, Wei M, Gao AK, Chuah YH, Sachaphibulkij K, Bonne I, Lim KJ, Sinha I, Teh DBL, Lim LHK, Kumar P, Verma NK, Sze NSK, Lim EH, Ong DST, Cheong JK, Itahana K, Connolly JE, Crasta KC.
Extracellular vesicles from therapy-induced senescent tumour cells suppress breast cancer via DKK1-mediated inflammatory responses. bioRxiv. 2024.
Robert M, Kennedy BK#, Crasta KC#.
Therapy-induced senescence through the redox lens. Redox Biology. 2024;74:103228.
https://doi.org/10.1016/j.redox.2024.103228
(# Corresponding authors)
Feng J, Chuah YH, Liang Y, Cipta NO, Zeng Y, Warrier T, Elfar GARE, Yoon J, Grinchuk OV, Tay EXY, Lok KZ, Zheng ZQ, Khong ZJ, Chong ZS, Teo J, Sanford EM, Neo CJY, Chiu HY, Leung JY, Wang LC, Lim YT, Zhao T, Sobota RM, Crasta KC, Tergaonkar V, Taneja R, Ng SY, Cheok CF, Ling SC, Loh YH, Ong DST.
PHF2 regulates genome topology and DNA replication in neural stem cells via cohesin. Nucleic Acids Research. 2024.
https://doi.org/10.1093/nar/gkae457
Guan L, Eisenmenger A, Crasta KC, Sandalova E, Maier AB.
Therapeutic effects of dietary ingredients on cellular senescence in animals and humans: A systematic review. Ageing Research Reviews. 2024;95:102238.
https://doi.org/10.1016/j.arr.2024.102238
2023
Chuah YH, Tay EXY, Grinchuk OV, Yoon J, Feng J, Kannan S, Robert M, Jakhar R, Liang Y, Lee BWL, Wang LC, Lim YT, Zhao T, Sobota RM, Lu G, Low BC, Crasta KC, Verma CS, Lin Z, Ong DST.
CAMK2D scaffolds the RNF8–MAD2 complex to induce mitotic checkpoint activation in glioma. Cell Death & Differentiation. 2023;30:1973–1987.
https://doi.org/10.1038/s41418-023-01192-3
Elazary Y, Cheow K, Cheng RK, Ghosh R, Shainer I, Wexler Y, Crasta KC, Gothilf Y, Jesuthasan SJ.
Glial cells expressing visual cycle genes are vital for photoreceptor survival in the zebrafish pineal gland. Journal of Pineal Research. 2023;74:e12854.
https://doi.org/10.1111/jpi.12854
2022
Guan L, Crasta KC, Maier AB.
Assessment of cell cycle regulators in human peripheral blood cells as markers of cellular senescence. Ageing Research Reviews. 2022;78:101634.
https://doi.org/10.1016/j.arr.2022.101634
Srinivas US, Tay NSC, Jaynes P, et al., Crasta KC, et al.
PLK1 inhibition selectively induces apoptosis in ARID1A-deficient cells by uncoupling oxygen consumption from ATP production. Oncogene. 2022;41:1986–2002.
https://doi.org/10.1038/s41388-022-02219-8
Yoon J, Grinchuk OV, Tirado-Magallanes R, et al., Crasta KC, Ong DST.
E2F and STAT3 transcriptional synergy sustains glioblastoma chromatin accessibility and tumorigenicity. Cell Death & Differentiation. 2022;29:1379–1394.
https://doi.org/10.1038/s41418-021-00926-5
Robert M, Crasta KC.
Extrachromosomal circular DNA as an emerging player in tumour evolution. Seminars in Cell & Developmental Biology. 2022;123:140–150.
https://doi.org/10.1016/j.semcdb.2021.11.015
Crasta KC.
Chromothripsis: A shattered chromosome in the spotlight. Seminars in Cell & Developmental Biology. 2022;123:88–89.
https://doi.org/10.1016/j.semcdb.2021.11.021
+ All publications above are outcomes of work started at NUS.
2020 and Earlier (Pre-NUS)
Ku JWK, Chen Y, Lim BJW, Gasser S, Crasta KC, Gan YH.
Bacterial-induced cell fusion triggers cGAS–STING activation via micronuclei formation. PNAS. 2020;117:15923–15934.
https://doi.org/10.1073/pnas.2006908117
Tay VSY, Devaraj S, Koh T, Ke G, Crasta KC, Ali Y.
Double-strand breaks and p21-mediated responses in diabetic β-cells. Scientific Reports. 2019;9:19341.
https://doi.org/10.1038/s41598-019-54554-8
Jakhar R, Crasta KC.
Exosomes as emerging mediators of the senescence-associated secretory phenotype. International Journal of Molecular Sciences. 2019;20:2547.
https://doi.org/10.3390/ijms20102547
Wong A, Chen S, Yang LK, Kanagasundaram Y, Crasta KC.
Lipid accumulation facilitates mitotic slippage-induced drug adaptation. Cell Death Discovery. 2018;4:109.
https://doi.org/10.1038/s41420-018-0127-5
Jakhar R, et al., Crasta KC.
Autophagy governs protumorigenic effects of mitotic slippage-induced senescence. Molecular Cancer Research. 2018;16:1625–1640.
https://doi.org/10.1158/1541-7786.MCR-18-0024
(Featured in Highlights of This Issue)
Shyu P Jr*, Wong AXF*, Crasta KC#, Thibault G#.
Dropping in on lipid droplets: Insights into cellular stress and cancer. Bioscience Reports. 2018;38:BSR20180764.
https://doi.org/10.1042/BSR20180764
He Q, et al., Crasta KC.
Chromosomal instability-induced senescence potentiates non-cell-autonomous tumourigenic effects. Oncogenesis. 2018;7:62.
https://doi.org/10.1038/s41389-018-0072-4
Luijten MNH, Lee JXT, Crasta KC.
Chromothripsis and its emerging relevance to cancer. Mutation Research Reviews. 2018;777:29–51.
https://doi.org/10.1016/j.mrrev.2018.06.004
Luijten MNH, Lee JXT, Chen S, Crasta KC.
Generation of micronuclei and detection of chromosome pulverization. Methods in Molecular Biology. 2018;1769:183–195.
https://doi.org/10.1007/978-1-4939-7780-2_12
Cheng B, Crasta KC.
Consequences of mitotic slippage for antimicrotubule therapy. Endocrine-Related Cancer. 2017;24:T97–T106.
Crasta KC, Aneja R.
Fifty years on: Tubulin discovery continues to advance cancer treatment. Endocrine-Related Cancer. 2017;24:E3–E5.
Cheng B, Crasta KC.
Autophagy, cellular senescence and cancer. In: Autophagy and Signaling. CRC Press; 2017:67–90.
https://doi.org/10.1201/9781315120638
Ku JWK, Chen Y, Lim BJW, Gasser S, Crasta KC, Gan YH.
Bacterial-induced cell fusion triggers cGAS–STING activation via micronuclei formation. PNAS. 2020;117:15923–15934.
https://doi.org/10.1073/pnas.2006908117
Tay VSY, Devaraj S, Koh T, Ke G, Crasta KC, Ali Y.
Double-strand breaks and p21-mediated responses in diabetic β-cells. Scientific Reports. 2019;9:19341.
https://doi.org/10.1038/s41598-019-54554-8
Jakhar R, Crasta KC.
Exosomes as emerging mediators of the senescence-associated secretory phenotype. International Journal of Molecular Sciences. 2019;20:2547.
https://doi.org/10.3390/ijms20102547
Wong A, Chen S, Yang LK, Kanagasundaram Y, Crasta KC.
Lipid accumulation facilitates mitotic slippage-induced drug adaptation. Cell Death Discovery. 2018;4:109.
https://doi.org/10.1038/s41420-018-0127-5
Jakhar R, et al., Crasta KC.
Autophagy governs protumorigenic effects of mitotic slippage-induced senescence. Molecular Cancer Research. 2018;16:1625–1640.
https://doi.org/10.1158/1541-7786.MCR-18-0024
(Featured in Highlights of This Issue)
Shyu P Jr*, Wong AXF*, Crasta KC#, Thibault G#.
Dropping in on lipid droplets: Insights into cellular stress and cancer. Bioscience Reports. 2018;38:BSR20180764.
https://doi.org/10.1042/BSR20180764
He Q, et al., Crasta KC.
Chromosomal instability-induced senescence potentiates non-cell-autonomous tumourigenic effects. Oncogenesis. 2018;7:62.
https://doi.org/10.1038/s41389-018-0072-4
Luijten MNH, Lee JXT, Crasta KC.
Chromothripsis and its emerging relevance to cancer. Mutation Research Reviews. 2018;777:29–51.
https://doi.org/10.1016/j.mrrev.2018.06.004
Luijten MNH, Lee JXT, Chen S, Crasta KC.
Generation of micronuclei and detection of chromosome pulverization. Methods in Molecular Biology. 2018;1769:183–195.
https://doi.org/10.1007/978-1-4939-7780-2_12
Cheng B, Crasta KC.
Consequences of mitotic slippage for antimicrotubule therapy. Endocrine-Related Cancer. 2017;24:T97–T106.
Crasta KC, Aneja R.
Fifty years on: Tubulin discovery continues to advance cancer treatment. Endocrine-Related Cancer. 2017;24:E3–E5.
Cheng B, Crasta KC.
Autophagy, cellular senescence and cancer. In: Autophagy and Signaling. CRC Press; 2017:67–90.
https://doi.org/10.1201/9781315120638
Early Work in Mitotic Regulation and Cancer Biology
My early research laid the foundation for my long-standing interest in mitotic regulation, chromosomal instability, and cancer biology. This work spans my undergraduate, doctoral, and postdoctoral training, and shaped the scientific questions that continue to drive the Crasta Lab today.
Selected Early Publications
2012
Crasta K, Ganem NJ, Dagher R, Lantermann AB, Ivanova EV, Potopova A, Pan Y, Nezi L, Chowdhury D, Pellman D.
DNA breaks and chromosome pulverization from errors in mitosis. Nature 482: 53–58.
2008
Crasta K, Lim HH, Giddings TJ, Winey M, Surana U.
Inactivation of Cdh1 by synergistic action of Cdk1 and Polo kinase is required for bipolar spindle assembly. Nature Cell Biology 10: 665–675.
Crasta K, Lim HH, Zhang T, Nirantar S, Surana U.
Consorting kinases, end of destruction and birth of a spindle. Cell Cycle 7: 2960–2966.
2006
Crasta K, Huang P, Morgan G, Winey M, Surana U.
Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins. EMBO Journal 25: 2551–2563.
Crasta K, Surana U.
Disjunction of conjoined twins: Cdk1, Cdh1 and centrosome separation. Cell Division 1: 12–14.
2004
Krishnan V, Nirantar S, Crasta K, Cheng AYH, Surana U.
The DNA replication checkpoint prevents precocious chromosome segregation by regulating spindle behaviour. Molecular Cell 16: 687–700.
Undergraduate Research
My first peer-reviewed publication, completed as an undergraduate at NUS, sealed my love for scientific discovery and research.
2002
Crasta KC, Chua KL, Subramaniam S, Frey J, Loh H, Tan HM.
Identification and characterisation of CAMP co-hemolysin as a potential virulence factor of Riemerella anatipestifer. Journal of Bacteriology 184(7): 1932–1939.
My early research laid the foundation for my long-standing interest in mitotic regulation, chromosomal instability, and cancer biology. This work spans my undergraduate, doctoral, and postdoctoral training, and shaped the scientific questions that continue to drive the Crasta Lab today.
Selected Early Publications
2012
Crasta K, Ganem NJ, Dagher R, Lantermann AB, Ivanova EV, Potopova A, Pan Y, Nezi L, Chowdhury D, Pellman D.
DNA breaks and chromosome pulverization from errors in mitosis. Nature 482: 53–58.
2008
Crasta K, Lim HH, Giddings TJ, Winey M, Surana U.
Inactivation of Cdh1 by synergistic action of Cdk1 and Polo kinase is required for bipolar spindle assembly. Nature Cell Biology 10: 665–675.
Crasta K, Lim HH, Zhang T, Nirantar S, Surana U.
Consorting kinases, end of destruction and birth of a spindle. Cell Cycle 7: 2960–2966.
2006
Crasta K, Huang P, Morgan G, Winey M, Surana U.
Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins. EMBO Journal 25: 2551–2563.
Crasta K, Surana U.
Disjunction of conjoined twins: Cdk1, Cdh1 and centrosome separation. Cell Division 1: 12–14.
2004
Krishnan V, Nirantar S, Crasta K, Cheng AYH, Surana U.
The DNA replication checkpoint prevents precocious chromosome segregation by regulating spindle behaviour. Molecular Cell 16: 687–700.
Undergraduate Research
My first peer-reviewed publication, completed as an undergraduate at NUS, sealed my love for scientific discovery and research.
2002
Crasta KC, Chua KL, Subramaniam S, Frey J, Loh H, Tan HM.
Identification and characterisation of CAMP co-hemolysin as a potential virulence factor of Riemerella anatipestifer. Journal of Bacteriology 184(7): 1932–1939.
For a continuously updated list of publications and citation metrics, please visit our Google Scholar profile.
https://scholar.google.com/citations?hl=en&user=nSgDF_8AAAAJ
https://scholar.google.com/citations?hl=en&user=nSgDF_8AAAAJ