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KC LAB PUBLICATIONS
2023
Yotam Elazary, Kathleen Cheow, Ruey-Kuang Cheng, Raghumoy Ghosh, Inbal Shainer, Yair Wexler, Karen Crasta, Yoav Gothilf and Suresh J. Jesuthasan.
Glial cells expressing visual cycle genes are vital for photoreceptor survival in the zebrafish pineal gland. Journal of Pineal Research (2023). Jan 24. doi: 10.1111/jpi.12854.
2022
Lihuan Guan, Karen Crasta and Andrea Maier. Assessment of cell cycle regulators in human peripheral blood cells as markers of cellular senescence. Ageing Research Reviews. (2022) Apr 20;78:101634. doi: 10.1016/j.arr.2022.101634.
Upadhyayula Srinivas, Tay S.C. Norbert, Patrick Jaynes, Akshaya Anbuselvan, Gokula Ramachandran, Joanna Wardyn, Michal Hoppe, Phuong Hoang, Yanfen Peng, Sherlly Lim, May Yin Lee, Praveen Peethala, Omer An, Akshay Shendre, Bryce W.Q. Tan, Sherlyn Jemimah, Manikandan Lakshmanan, Longyu Hu, Rekha Jakhar, Karishma Sachaphibulkij, Lina Lim, Shazib Pervaiz, Karen Crasta, Henry Yang, Patrick Tan, Chao Liang, Lena Ho, Vartika Khanchandani, Dennis Kappei, Yong Peng, David S.P. Tan, Matteo Bordi, Silvia Campello, Wai Leong Tam, and Christian Frezza, Anand Jeyasekharan. PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production. Oncogene 41, 1986–2002 (2022). https://doi.org/10.1038/s41388-022-02219-8
Jeehyun Yoon, Oleg Grinchuk, Roberto Tirado Magallanes, Zhen Kai Ngian, Emmy Tay, You Heng Chuah, Bernice Lee, Jia Feng, Karen Carmelina Crasta, Chin Tong Ong, Touati Benoukraf and Derrick Ong. E2F and STAT3 provide transcriptional synergy for histone variant H2AZ activation to sustain glioblastoma chromatin accessibility and tumorigenicity. Cell Death and Differentiation (2022). https://doi.org/10.1038/s41418-021-00926-5
Matius Robert and Karen Crasta. Breaking the vicious circle: Extrachromosomal circular DNA as an emerging player in tumour evolution. Seminars in Cell & Developmental Biology. 123: 140-150 (2022).
Karen Crasta. Chromothripsis: A shattered chromosome in the spotlight. Seminars in Cell & Developmental Biology. 123: 88-89 (2022).
+ All publications above are outcomes of work started at NUS.
Yotam Elazary, Kathleen Cheow, Ruey-Kuang Cheng, Raghumoy Ghosh, Inbal Shainer, Yair Wexler, Karen Crasta, Yoav Gothilf and Suresh J. Jesuthasan.
Glial cells expressing visual cycle genes are vital for photoreceptor survival in the zebrafish pineal gland. Journal of Pineal Research (2023). Jan 24. doi: 10.1111/jpi.12854.
2022
Lihuan Guan, Karen Crasta and Andrea Maier. Assessment of cell cycle regulators in human peripheral blood cells as markers of cellular senescence. Ageing Research Reviews. (2022) Apr 20;78:101634. doi: 10.1016/j.arr.2022.101634.
Upadhyayula Srinivas, Tay S.C. Norbert, Patrick Jaynes, Akshaya Anbuselvan, Gokula Ramachandran, Joanna Wardyn, Michal Hoppe, Phuong Hoang, Yanfen Peng, Sherlly Lim, May Yin Lee, Praveen Peethala, Omer An, Akshay Shendre, Bryce W.Q. Tan, Sherlyn Jemimah, Manikandan Lakshmanan, Longyu Hu, Rekha Jakhar, Karishma Sachaphibulkij, Lina Lim, Shazib Pervaiz, Karen Crasta, Henry Yang, Patrick Tan, Chao Liang, Lena Ho, Vartika Khanchandani, Dennis Kappei, Yong Peng, David S.P. Tan, Matteo Bordi, Silvia Campello, Wai Leong Tam, and Christian Frezza, Anand Jeyasekharan. PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production. Oncogene 41, 1986–2002 (2022). https://doi.org/10.1038/s41388-022-02219-8
Jeehyun Yoon, Oleg Grinchuk, Roberto Tirado Magallanes, Zhen Kai Ngian, Emmy Tay, You Heng Chuah, Bernice Lee, Jia Feng, Karen Carmelina Crasta, Chin Tong Ong, Touati Benoukraf and Derrick Ong. E2F and STAT3 provide transcriptional synergy for histone variant H2AZ activation to sustain glioblastoma chromatin accessibility and tumorigenicity. Cell Death and Differentiation (2022). https://doi.org/10.1038/s41418-021-00926-5
Matius Robert and Karen Crasta. Breaking the vicious circle: Extrachromosomal circular DNA as an emerging player in tumour evolution. Seminars in Cell & Developmental Biology. 123: 140-150 (2022).
Karen Crasta. Chromothripsis: A shattered chromosome in the spotlight. Seminars in Cell & Developmental Biology. 123: 88-89 (2022).
+ All publications above are outcomes of work started at NUS.
KC LAB MOVED TO THE NATIONAL UNIVERSITY OF SINGAPORE (NUS) IN 2021.
JWK Ku, Y Chen, BJW Lim, S Gasser, KC Crasta, YH Gan (2020). Bacterial-induced cell fusion is a danger signal triggering cGAS–STING pathway via micronuclei formation. Proceedings of the National Academy of Sciences 117 (27), 15923-15934.
VSY Tay, S Devaraj, T Koh, G Ke, KC Crasta, Y Ali (2019). Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis. Scientific Reports 9, 19341.
R Jakhar, K Crasta (2019). Exosomes as emerging pro-tumorigenic mediators of the senescence-associated secretory phenotype. International Journal of Molecular Sciences 20 (10), 2547.
A Wong, S Chen, LK Yang, Y Kanagasundaram, K Crasta (2018). Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment. Cell Death Discovery 4 (1), 1-15.
Rekha Jakhar*, Monique NH Luijten*, Alex XF Wong*, Bing Cheng, Ke Guo, Suat P Neo, Bijin Au, Madhura Kulkarni, Kah J Lim, Jiamila Maimaiti, Han C Chong, Elaine H Lim, Tee BK Tan, Kong W Ong, Yirong Sim, Jill SL Wong, James BK Khoo, Juliana TS Ho, Boon T Chua, Indrajit Sinha, Xiaomeng Wang, John E Connolly, Jayantha Gunaratne, Karen C Crasta (2018). Autophagy governs protumorigenic effects of mitotic slippage–induced senescence. Molecular Cancer Research 16 (11), 1625-1640.
P Shyu*, XFA Wong*, K Crasta#, G Thibault# (2018). Dropping in on lipid droplets: insights into cellular stress and cancer. Bioscience Reports 38 (5).
Qianqian He, Bijin Au, Madhura Kulkarni, Yang Shen, Kah J Lim, Jiamila Maimaiti, Cheng Kit Wong, Monique NH Luijten, Han C Chong, Elaine H Lim, Giulia Rancati, Indrajit Sinha, Zhiyan Fu, Xiaomeng Wang, John E Connolly, Karen C Crasta (2018). Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects. Oncogenesis. 7 (8), 1-18.
MNH Luijten, JXT Lee, KC Crasta (2018). Mutational game changer: Chromothripsis and its emerging relevance to cancer. Mutation Research/ Reviews in Mutation Research 777, 29-51.
Monique NH Luijten, Jeannie XT Lee, Sixun Chen, Karen C Crasta (2018). Generation of micronuclei and detection of chromosome pulverization. Chapter 12 pp 183-195. in Chromothripsis. Humana Press, New York, NY.
K Crasta#, R Aneja# (2017). 50 years on… the discovery of tubulin continues to advance cancer treatment. Endocrine-Related Cancer 24 (9), E3-E5. Invited Guest Editor for Special Issue on "50 years of discovery of Tubulin".
B Cheng, K Crasta (2017). Consequences of mitotic slippage for antimicrotubule drug therapy. Endocrine-Related Cancer 24 (9), T97-T106.
B Cheng, K Crasta (2017). Autophagy, Cellular Senescence and Cancer. Chapter 4 pp 67-90. in Autophagy and Signaling. CRC Press, Taylor and Francis Group. https://doi.org/10.1201/9781315120638.
Early Exposure in Mitotic Regulation and Cancer Biology:
2012 Crasta K., Ganem N., Dagher R., Lantermann A., Ivanova E., Potopova A., Yunfeng P., Nezi L., Chowdhury D and
Pellman D. DNA breaks and chromosome pulverization from errors in mitosis. Nature 482: 53-58.
2008 Crasta K., Lim H. H., Giddings,T.J. ,Winey M. and Surana U. Inactivation of Cdh1 by synergistic action of Cdk1 and
Polo kinase is necessary for proper assembly of a bipolar spindle. Nat Cell Biol 10: 665-675.
Crasta K., Lim H.H, Zhang T., Nirantar S. and Surana U. Consorting kinases, end of destruction and birth of a spindle.
Cell Cycle 7: 2960-2966.
2006 Crasta K., Huang P., Morgan G., Winey M. and Surana, U. Cdk1 regulates centrosome separation by restraining
proteolysis of microtubule-associated proteins. EMBO J. 25: 2551-2563.
Crasta K. and Surana U. Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes. Cell Div 1: 12-14.
2004 Krishnan V., Nirantar S., Crasta K., Cheng A.Y.H. and Surana U. DNA replication checkpoint prevents
precocious chromosome segregation by regulating spindle behavior. Mol Cell 16: 687-700.
My publication as a NUS undergraduate on a study that sealed my love for scientific discovery .....
2002 Crasta K.C., Chua K.L., Subramaniam S., Frey J., Loh H. and Tan H.M. Identification and Characterization of CAMP Cohemolysin as a Potential Virulence Factor of Riemerella anatipestifer. J Bacteriol 184(7): 1932-1939.